ACTN3 genotype influences muscle performance through the regulation of calcineurin signaling
نویسندگان
چکیده
منابع مشابه
ACTN3 Genotype Association with Motoric Performance of Roma Children
The paper presents the results of the molecular genetics analysis in sports research, with special emphasis to use genetic information in diagnosing of motoric predispositions in Roma boys from East Slovakia. The ability and move are the basic characteristics of all living organisms. The phenotypes are influenced by a combination of genetic and environmental factors. Genetic tests differ in pri...
متن کاملACTN3 and MLCK genotype associations with exertional muscle damage.
Strenuous exercise results in damage to skeletal muscle that is manifested in delayed muscle pain, prolonged strength loss, and increases in muscle proteins in the blood, especially creatine kinase (CK) and myoglobin (Mb). Some individuals experience profound changes in these variables in response to standard laboratory exercise or recreational activities. We proposed that variations in genes c...
متن کاملCalcineurin Signaling and Muscle Remodeling
2ϩ-calmodulin, participates in signaling pathways valvular dysfunction, from ischemic injury following cor-important for gene regulation and biological responses onary artery occlusion, or from mutations in genes en-to external stimuli in many organisms and in many types coding proteins of the sarcomere. Initially, this remodel-of cells (Crabtree, 1999). Calcineurin-dependent signal-ing respons...
متن کاملACTN3 genotype is associated with human elite athletic performance.
There is increasing evidence for strong genetic influences on athletic performance and for an evolutionary "trade-off" between performance traits for speed and endurance activities. We have recently demonstrated that the skeletal-muscle actin-binding protein alpha-actinin-3 is absent in 18% of healthy white individuals because of homozygosity for a common stop-codon polymorphism in the ACTN3 ge...
متن کاملACTN3: A genetic influence on muscle function and athletic performance.
A common variant of the ACTN3 gene, R577X, results in complete deficiency of the alpha-actinin-3 protein in the fast skeletal muscle fibers of more than a billion humans worldwide. We review the evidence that this genetic variant is strongly associated with elite athlete status and with normal variation in human muscle strength and sprinting speed.
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2013
ISSN: 0021-9738
DOI: 10.1172/jci67691